Sparse production but preferential incorporation of recently produced naı̈ve T cells in the human peripheral pool
نویسندگان
چکیده
*Department of Immunology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands; †Department of Clinical Viro-Immunology, Sanquin Research Center, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1000 GG, Amsterdam, The Netherlands; Departments of ‡Clinical Chemistry and §Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1100 DD, Amsterdam, The Netherlands; and ¶Department of Theoretical Biology, Utrecht University, 3584 CH, Utrecht, The Netherlands
منابع مشابه
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.
In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although (2)H(2)O labeling in young mice showed high thymic-dependent daily naïve T cell production, long term up- and down-labeling with (2)H(2)O in human adults revealed a low daily pr...
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تاریخ انتشار 2008